Holy Cross, IA has a population of 339 and is the 21,796th largest city in the United States. The population density is 1,035 per sq mi which is 1794% higher than the Iowa average and 1042% higher than the national average. The median age in Holy Cross is 42 which is approximately 10% higher than the Iowa average of 38. In Holy Cross, 68% of the population over 15 years of age are married, 99% speak English and 1% speak Spanish. 94% of Holy Cross residents were born in Iowa, 6% were born out of state, 0% were born outside of the United States and 0% were foreign born.