De Soto, IA has a population of 1,065 and is the 14,758th largest city in the United States. The population density is 698 per sq mi which is 1178% higher than the Iowa average and 671% higher than the national average. The median age in De Soto is 34 which is approximately 12% lower than the Iowa average of 38. In De Soto, 57% of the population over 15 years of age are married, 99% speak English and 0% speak Spanish. 82% of De Soto residents were born in Iowa, 18% were born out of state, 0% were born outside of the United States and 0% were foreign born.