De Pere, WI has a population of 24,544 and is the 1,773rd largest city in the United States. The population density is 2,110 per sq mi which is 2314% higher than the Wisconsin average and 2229% higher than the national average. The median age in De Pere is 35 which is approximately 10% lower than the Wisconsin average of 39. In De Pere, 56% of the population over 15 years of age are married, 95% speak English and 3% speak Spanish. 75% of De Pere residents were born in Wisconsin, 22% were born out of state, 1% were born outside of the United States and 2% were foreign born.