| Index | Clayton | Missouri | National | 
| Average Test Scores | 73% | 44% | 48% | 
| Student/Teacher ratio | 17:1 | 14:1 | 16:1 | 
| Total public schools | 7 | 1,899 | 79,221 | 
| Total private schools | 2 | 531 | 24,874 | 
| Total post-secondary schools | n/a | 213 | 7,963 | 

 
				
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				| Index | Clayton | Missouri | National | 
| Completed 8th grade | 95.7% | 86.0% | 84.3% | 
| Completed high school | 95.2% | 84.2% | 83.0% | 
| Completed some college | 90.4% | 57.7% | 59.4% | 
| Completed associate degree | 80.7% | 35.2% | 38.5% | 
| Completed bachelors | 78.7% | 27.6% | 30.3% | 
| Completed masters | 45.4% | 10.4% | 11.5% | 
| Completed professional degree | 22.3% | 2.8% | 3.3% | 
| Completed doctorate | 9.1% | 1.2% | 1.3% | 
There are a total of 7 public schools, 2 private schools and n/a post-secondary schools in Clayton. Using the proficiency score averages, the average test scores for Clayton, MO schools is 73%. The average student to teacher ratio is 17:1. In Clayton, MO, an average of 95.7% of students have completed 8th grade and an average of 95.2% have completed high school.
| City | Population | Avg. Test Scores | National Avg. | 
| Brentwood, MO | 7,986 | 70% | 45.6% | 
| Olivette, MO | 7,837 | 70% | 44.8% | 
| Chesterfield, MO | 47,603 | 69% | 43.2% | 
| Kirkwood, MO | 27,772 | 69% | 43.1% | 
| Webster Groves, MO | 22,906 | 64% | 32.8% | 
| Clayton, MO | 16,763 | 73% | 52.7% | 
| City | Population | Avg. Test Scores | National Avg. | 
| Defiance, OH | 16,741 | 70% | 46.3% | 
| Knightdale, NC | 16,798 | 27% | 43.3% | 
| Seagoville, TX | 16,726 | 54% | 11.5% | 
| Danville, KY | 16,801 | 55% | 13.5% | 
| Cohoes, NY | 16,708 | 52% | 8.5% | 
| Clayton, MO | 16,763 | 73% | 52.7% |