Cherokee, IA has a population of 5,113 and is the 6,369th largest city in the United States. The population density is 782 per sq mi which is 1331% higher than the Iowa average and 763% higher than the national average. The median age in Cherokee is 44 which is approximately 16% higher than the Iowa average of 38. In Cherokee, 57% of the population over 15 years of age are married, 97% speak English and 3% speak Spanish. 73% of Cherokee residents were born in Iowa, 25% were born out of state, 0% were born outside of the United States and 2% were foreign born.