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| Month | Temp. (min) | Temp. (max) | Temp. (avg) | Precipitation |
| January | 65°F | 77°F | 71°F | 2.2" |
| February | 64°F | 77°F | 70°F | 4.1" |
| March | 68°F | 80°F | 74°F | 4.1" |
| April | 70°F | 82°F | 76°F | 5.9" |
| May | 75°F | 86°F | 80°F | 5.5" |
| June | 77°F | 89°F | 82°F | 10.3" |
| July | 80°F | 91°F | 85°F | 7.7" |
| August | 79°F | 91°F | 85°F | 10.4" |
| September | 78°F | 90°F | 84°F | 9.6" |
| October | 78°F | 87°F | 82°F | 5.1" |
| November | 71°F | 82°F | 76°F | 0.7" |
| December | 68°F | 80°F | 73°F | 2.0" |
| Index | Duck Key | Florida | National |
| Air quality index | 41 | 35 | 42 |
| Pollution index | 43,296,200 | 7,570,785 | 2,726,193 |
| Measurement | Total |
| Days measured | 363 |
| Days with good air quality | 284 |
| Days with moderate air quality | 77 |
| Days w/ poor A.Q. for sensitive groups | 2 |
| Days with unhealthy air quality | 0 |
| Pollutant | Total |
| Arsenic | 0.060% |
| Benzene | 0.510% |
| Carbon Tetrachloride | 0.150% |
| Lead | 0.330% |
| Mercury | 0.090% |
| City | Population | Air Quality Index | National Avg. |
| Layton, FL | 107 | 41 | 18.0% |
| Marathon, FL | 8,746 | 41 | 18.0% |
| Key Colony Beach, FL | 523 | 41 | 18.0% |
| Duck Key, FL | 761 | 41 | 18.0% |
| City | Population | Air Quality Index | National Avg. |
| Manokotak, AK | 761 | 31 | 38.0% |
| Independence, CA | 761 | 47 | 6.0% |
| Ventura, IA | 761 | 15 | 70.0% |
| Challis, ID | 761 | 36 | 28.0% |
| Mount Hope, KS | 761 | 40 | 20.0% |
| Duck Key, FL | 761 | 41 | 18.0% |