| Index | Chamberlain | South Dakota | National |
| Income per capita | $35,130 | $27,516 | $29,829 |
| Median household income | $50,461 | $52,078 | $55,322 |
| Median income owner occupied | $63,571 | $66,299 | $70,586 |
| Median income renter occupied | $31,581 | $30,800 | $35,192 |
| Median earnings male | $40,859 | $35,140 | $36,919 |
| Median earnings female | $29,667 | $24,451 | $26,250 |
| Unemployment rate | 1.8% | 2.8% | 4.7% |
| Poverty level | 16.3% | 14.0% | 15.1% |


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| Labour Type | Male | Female |
| Construction industry | 3.2% | 3.2% |
| Manufacturing sector | 0.0% | 0.0% |
| Financial & insurance services | 6.5% | 6.5% |
| Wholesale & retail services | 6.0% | 6.0% |
| Public administration | 21.6% | 21.6% |
| Transportation, warehousing & utilities | 3.9% | 3.9% |
| Education, health & social services | 26.2% | 26.2% |
| Other | 30.2% | 30.2% |
| City | Population | Household Income | National Avg. |
| Oacoma, SD | 375 | $65,714 | 18.8% |
| Pukwana, SD | 356 | $60,625 | 9.6% |
| Reliance, SD | 109 | $54,375 | 1.7% |
| Ola, SD | 0 | $0 | 100.0% |
| Chamberlain, SD | 2,549 | $50,461 | 8.8% |
| City | Population | Household Income | National Avg. |
| Vassar, MI | 2,549 | $40,719 | 26.4% |
| Agua Dulce, TX | 2,549 | $33,986 | 38.6% |
| Esterhazy, SK | 2,549 | n/a | |
| Center Point, IA | 2,548 | $64,815 | 17.2% |
| Alturas, CA | 2,550 | $40,921 | 26.0% |
| Chamberlain, SD | 2,549 | $50,461 | 8.8% |