| Statistic | Cherokee Seneca | Louisville | Kentucky |
| Population | 1,515 | 611,573 | 4,411,989 |
| Population density (sq mi) | 531 | 2,319 | 108 |
| Median age | 35.8 | 37.3 | 38.6 |
| Male/Female ratio | 1.1:1 | 0.9:1 | 1.0:1 |
| Married (15yrs & older) | n/a | 50% | 58% |
| Speak English | n/a | 91% | 95% |
| Speak Spanish | n/a | 4% | 3% |
| Race | Cherokee Seneca | Louisville | Kentucky |
| Caucasian | 89.49% | 70.88% | 87.48% |
| African American | 2.72% | 22.88% | 7.94% |
| Asian | 1.94% | 2.43% | 1.29% |
| American Indian | 0.00% | 0.12% | 0.21% |
| Native Hawaiian | 0.00% | 0.06% | 0.06% |
| Mixed race | 4.19% | 3.06% | 2.10% |
| Other race | 1.66% | 0.58% | 0.92% |