An overview of the general cost of living index for Sikeston, MO is displayed above for your reference. Residents in Sikeston, MO enjoy a cost of living index of 80. This index is 12% lower than the Missouri average, and 20% lower than the national average. The following categories are used when determining the cost of living index for any given city: health care (5%), transportation (9%), utilities (10%), groceries (13%), housing (30%), and goods/services (33%). Clearly, housing and goods/services make up the majority of the formula for calculating the cost of living index. Because of this, the general cost of living for any given area can be estimated by looking at the cost of everyday goods in that area. For those living in Sikeston, MO, the average cost of goods and services is 5% lower than it is in Missouri, and it is 9% lower than the national average.