| Index | Sikeston | Missouri | National |
| Average Test Scores | 34% | 44% | 48% |
| Student/Teacher ratio | 12:1 | 14:1 | 16:1 |
| Total public schools | 15 | 1,899 | 79,221 |
| Total private schools | 2 | 531 | 24,874 |
| Total post-secondary schools | 1 | 213 | 7,963 |
| Index | Sikeston | Missouri | National |
| Completed 8th grade | 83.5% | 86.0% | 84.3% |
| Completed high school | 80.9% | 84.2% | 83.0% |
| Completed some college | 47.6% | 57.7% | 59.4% |
| Completed associate degree | 24.9% | 35.2% | 38.5% |
| Completed bachelors | 19.5% | 27.6% | 30.3% |
| Completed masters | 8.5% | 10.4% | 11.5% |
| Completed professional degree | 2.3% | 2.8% | 3.3% |
| Completed doctorate | 0.6% | 1.2% | 1.3% |
There are a total of 15 public schools, 2 private schools and 1 post-secondary schools in Sikeston. Using the proficiency score averages, the average test scores for Sikeston, MO schools is 34%. The average student to teacher ratio is 12:1. In Sikeston, MO, an average of 83.5% of students have completed 8th grade and an average of 80.9% have completed high school.
| City | Population | Avg. Test Scores | National Avg. |
| Matthews, MO | 635 | 72% | 50.0% |
| Oran, MO | 1,285 | 61% | 26.6% |
| Bell City, MO | 494 | 52% | 8.3% |
| Benton, MO | 885 | 42% | 12.2% |
| East Prairie, MO | 2,980 | 34% | 28.8% |
| Sikeston, MO | 16,664 | 34% | 30.2% |
| City | Population | Avg. Test Scores | National Avg. |
| Truckee, CA | 16,666 | 53% | 11.2% |
| Madison, NJ | 16,647 | 73% | 51.0% |
| McKinleyville, CA | 16,645 | 39% | 19.0% |
| Mount Vernon, OH | 16,684 | 72% | 49.0% |
| North Myrtle Beach, SC | 16,684 | 67% | 39.6% |
| Sikeston, MO | 16,664 | 34% | 30.2% |
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