An overview of the general cost of living index for Picayune, MS is displayed above for your reference. Residents in Picayune, MS enjoy a cost of living index of 88. This index is 5% higher than the Mississippi average, and 12% lower than the national average. The following categories are used when determining the cost of living index for any given city: health care (5%), transportation (9%), utilities (10%), groceries (13%), housing (30%), and goods/services (33%). Clearly, housing and goods/services make up the majority of the formula for calculating the cost of living index. Because of this, the general cost of living for any given area can be estimated by looking at the cost of everyday goods in that area. For those living in Picayune, MS, the average cost of goods and services is 5% higher than it is in Mississippi, and it is 3% lower than the national average.