Compared to the other cities in Missouri and cities in all other U.S. states, how safe is Kirksville, MO? From the gauges displayed above, you will notice that Kirksville, MO has been ranked safer than 46% of other cities in the state of Missouri. In addition, Kirksville, MO is safer than 41% of cities in the entire United States. To achieve these results, all Missouri and United States cities were analyzed to determine how many locations had a lower crime rate than Kirksville, MO. By studying this data, it was possible to determine that Kirksville, MO is below average in safety when compared with other United States cities.