Galena, MO has a population of 518 and is the 19,322nd largest city in the United States. The population density is 694 per sq mi which is 704% higher than the Missouri average and 667% higher than the national average. The median age in Galena is 33 which is approximately 14% lower than the Missouri average of 38. In Galena, 56% of the population over 15 years of age are married, 99% speak English and 1% speak Spanish. 54% of Galena residents were born in Missouri, 45% were born out of state, 1% were born outside of the United States and 0% were foreign born.