East Prairie, MO has a population of 3,151 and is the 8,566th largest city in the United States. The population density is 2,437 per sq mi which is 2721% higher than the Missouri average and 2590% higher than the national average. The median age in East Prairie is 34 which is approximately 13% lower than the Missouri average of 38. In East Prairie, 59% of the population over 15 years of age are married, 100% speak English and 0% speak Spanish. 74% of East Prairie residents were born in Missouri, 26% were born out of state, 0% were born outside of the United States and 0% were foreign born.