| Index | Cape Girardeau | Missouri | National |
| Average Test Scores | 42% | 44% | 48% |
| Student/Teacher ratio | 11:1 | 14:1 | 16:1 |
| Total public schools | 15 | 1,899 | 79,221 |
| Total private schools | 9 | 531 | 24,874 |
| Total post-secondary schools | 5 | 213 | 7,963 |
| Index | Cape Girardeau | Missouri | National |
| Completed 8th grade | 86.9% | 86.0% | 84.3% |
| Completed high school | 85.4% | 84.2% | 83.0% |
| Completed some college | 64.5% | 57.7% | 59.4% |
| Completed associate degree | 39.8% | 35.2% | 38.5% |
| Completed bachelors | 34.1% | 27.6% | 30.3% |
| Completed masters | 13.3% | 10.4% | 11.5% |
| Completed professional degree | 4.0% | 2.8% | 3.3% |
| Completed doctorate | 2.1% | 1.2% | 1.3% |
There are a total of 15 public schools, 9 private schools and 5 post-secondary schools in Cape Girardeau. Using the proficiency score averages, the average test scores for Cape Girardeau, MO schools is 42%. The average student to teacher ratio is 11:1. In Cape Girardeau, MO, an average of 86.9% of students have completed 8th grade and an average of 85.4% have completed high school.
| City | Population | Avg. Test Scores | National Avg. |
| Jackson, MO | 14,893 | 50% | 3.3% |
| Jonesboro, IL | 1,772 | 46% | 5.2% |
| Benton, MO | 885 | 42% | 12.2% |
| Scott City, MO | 4,538 | 40% | 17.4% |
| Oak Ridge, MO | 241 | 35% | 28.1% |
| Cape Girardeau, MO | 40,100 | 42% | 11.6% |
| City | Population | Avg. Test Scores | National Avg. |
| Hollister, CA | 40,100 | 46% | 5.1% |
| San Gabriel, CA | 40,108 | 54% | 13.5% |
| Quincy, IL | 40,111 | 28% | 41.8% |
| Spanish Fork, UT | 40,069 | 45% | 6.5% |
| Montclair, CA | 40,041 | 45% | 6.1% |
| Cape Girardeau, MO | 40,100 | 42% | 11.6% |
Here are the best places to live in Missouri
10 best cities to buy a new house in Missouri
These are the 10 most affordable cities in Missouri
10 Best cities in Missouri for employment