AreaVibes reveals the best places to live in South Carolina for 2016 using our Livability Score. The Livability Score for each city in South Carolina is calculated out of 100 from a unique algorithm based on various metrics, including: amenities, cost of living, crime, education, employment, housing and weather. South Carolina has a population of 4,630,351 and a population density of 147.5 people per square mile. The capital city is Columbia and the largest city in South Carolina is Columbia. To filter the results, use the dropdown options to sort by population or category.